Description:

Successful weight loss with GLP-1 agonists

Summary Insights

• GLP-1 agonists are effective in weight loss as they delay gastric emptying, induce satiety, and decrease food
• These agents have been successfully studied in obese, non-diabetic patients
• Weight loss results seen as early as two weeks into treatment
• Liraglutide especially is shown to be effective for long-term (2 year) weight loss
• Liraglutide even produces greater weight loss results than orlistat
• More favorable effects on HbA1c and blood pressure seen with liraglutide vs. exenatide
• The enhanced satiety is a dose-dependent effect
• Combining soluble fiber with GLP-1 agonists increase weight loss results 

GLP-1 induces satiety, decreases food intake

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